Systemic circulation
Pulsatile membrane pump
A linear-drive pressure chamber designed for systemic pressure and controlled stroke delivery.
Technical details →Preclinical artificial-heart research · Freiburg
Building a modular artificial heart, one validated subsystem at a time.
Kanzler Biologicals is developing a research-stage circulatory support architecture that separates systemic flow, pulmonary flow, pulsatility, sensing and transcutaneous energy transfer into testable modules.
Development status: engineering concept and preclinical test planning. Not an approved medical device.
KB / System architectureConcept revision 06
06coordinated subsystems
130 mlsystemic stroke target
40–150beats/min concept range
16.5 l/minsystem output target
The engineering premise
One circulation.
Distinct technical jobs.
A total artificial heart must do more than move blood. It must manage two very different pressure regimes, reproduce useful pulsatility, react to changing demand and receive energy without creating unacceptable heat.
Our modular approach isolates these problems so each can be measured, challenged and improved before system integration.
Architecture
Designed as a system,
tested as modules.
Pulmonary circulation
Microaxial flow + pulse chamber
A low-pressure baseline pump paired with an independently controlled pulsatility module.
Technical details →Energy & control
Sensing, safety and TET
Redundant control logic, implantable energy storage and transcutaneous energy transfer.
Technical details →Evidence before claims
A transparent path from concept to bench evidence.
Target values are not test results. The project separates design assumptions, simulation, component testing and integrated validation so readers can see what is proposed—and what remains unproven.
See the validation plan →- 01Define
Requirements, interfaces, hazards and measurable acceptance criteria.
- 02Prototype
Module-level hardware for flow, pressure, heat and control testing.
- 03Verify
Repeatable bench protocols with documented inputs and outcomes.
- 04Integrate
Closed-loop system evaluation only after subsystem evidence exists.
Project status
Clear about what exists today.
Updated August 2026
System architecture
Functional decomposition, interfaces, target specifications, control concept and risk-driven validation roadmap.
Bench prototypes
Hydraulic characterization, hemocompatibility-oriented geometry refinement, thermal testing and fault-response verification.
Clinical performance
No clinical efficacy, safety, regulatory approval or patient-use claim is made by this research-stage project.
Collaboration
Hard biomedical problems are solved together.
We welcome focused exchange with researchers and engineers working in blood-contacting materials, pump design, controls, electronics, thermal management and preclinical testing.